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The component based SimBio environment will offer the ability for distributed, heterogeneous execution of its components. The Common Object Request Broker Architecture (CORBA) is the most appropriate client/server middleware for the object-oriented implementation of the SimBio system.

CORBA provides a high flexibility and enables the user to optimally exploit the computer resources being at his disposal. A CORBA object bus defines the "shape" of the SimBio components that reside within the bus and also fixes how these components interoperate. Beyond interoperability CORBA specifies an extensive set of bus-related services for creating and deleting objects, accessing them by name, externalising their states and defining ad hoc relationships between them. To make use of CORBA for SimBio an interface has to be specified for each component. These specifications are written in the Interface Definition Language (IDL) and define a component's boundary, i.e. a "contractual" interface with potential clients.

A particular example of the need for interacting components arises with the simulation of prosthesis implant, where close interactive links between the visualisation package, the material database, an external prosthesis database and the bio-mechanical solvers are required. The portability of CORBA will allow the SimBio-internal and SimBio-to-external interactions to take place in a seamless manner. The platform-independence of this approach is of decisive advantage in the clinical field as hospitals are often equipped with very heterogeneous computer clusters.